作者： Jin-Hong Ren;Hui-Qing Xue;Ye Liu;Yan-Ming Wei;Divid Adelson;Xue-Jing Chen;Jing-Hong Zhou;Jian-Dong Yu （College of Pharmaceutical and Food Engineering, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China. Experiment Centre, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China. Center of Bioinformatics and Computational Genetics, University of Adelaide, Adelaide 5005, Australia.）

出处： China journal of Chinese materia medica 2018

关键词： Astragalus membranaceus pathogenesis-related protein-10;papain inhibitor;ribonuclease activity

摘要： Astragalus membranaceus pathogenesis-related protein 10 (AmPR-10) is largely expressed in case of environmental pressure and pathogen invasion. This s ...

作者： Lanxiu Cao;Juan Lv;Xian Zhao;Jiang Wang;Li Ma （PhD, Department of Chinese Materia Medica, Shanxi University, Traditional Chinese Medicine, Shanxi, China. Conception and design of the study, acquisition of data, technical procedures, manuscript preparation and writing, final approval. Graduate student, Department of Chinese Materia Medica, Shanxi University, Traditional Chinese Medicine, Shanxi, China. Technical procedures, acquisition of data. PhD, Department of Chinese Materia Medica, Shanxi University, Traditional Chinese Medicine, Shanxi province, China. Statistical analysis, interpretation of data.）

出处： Acta cirurgica brasileira 2018

摘要： To investigate the efficacy and mechanisms of root tuber of Polygonum ciliinerve (Nakai) ohwi (rPC) which has been used to treat bacterial infection i ...

作者： Wei-Yu Zhu;Xia Feng;Jin Wang;Yu-Pan Lu;Xian-Zhe Dong;Ping Liu （Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China. Outpatient Department of the 61st Research Institute of the PLA General Staff Headquarters, Beijing 100041, China. Department of Graduate, Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China.）

出处： China journal of Chinese materia medica 2018

关键词： Dingzhi Xiaowan;SERT;depression;miR-16

摘要： This study is to investigate the effect of antidepressant medicine prescription Dingzhi Xiaowan (DZ) on miR-16 expression levels in vitro and in vivo, ...

作者： Bo Wang;Rong-Rong Zhou;Shi-Huan Tang （Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. School of Basic Medical Sciences, Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.）

出处： China journal of Chinese materia medica 2018

关键词： Dictionary of Traditional Chinese Medicine Prescriptions;Xiaoke disease;core herbs;functionary targets;integrative pharmacology;traditional Chinese medicine inheritance support system

摘要： Based on the database of 'Dictionary of Traditional Chinese Medicine Prescriptions', high-frequency herbs of Xiaoke disease is mined by traditional Ch ...

作者： Qing-Fang Gu;Jie-Zhong Yu;Hao Wu;Yan-Hua Li;Chun-Yun Liu;Ling Feng;Guang-Xian Zhang;Bao-Guo Xiao;Cun-Gen Ma （Department of Neurology, Institute of Brain Science, Medical School, Shanxi Datong University, Datong, Shanxi 037009, P.R. China. Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200025, P.R. China. 2011 Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi 030024, P.R. China.）

出处： Experimental and therapeutic medicine 2018

关键词： APP/PS1transgenic mice;Alzheimer's disease;FSD-C10;Rho kinase

摘要： Fasudil, a Rho kinase (ROCK) inhibitor, effectively inhibits disease severity in a mouse model of Alzheimer's disease (AD). However, given its signifi ...

作者： Qiao, X.;Li, Y.;Mai, J.;Ji, X.;Li, Q. （a School of Pharmaceutical Science, Shanxi Medical University, Taiyuan, 030001, China; b Department of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Jinzhong, 030619, China）

出处： Molecules 2018

关键词： Dibutyltin dilaurate (DBTD);MTOR pathway;PPARα;SREBP1C;Triglycerides metabolism

摘要： Dibutyltin dilaurate (DBTD) has multiple applications in daily life. However, DBTD is easily deposited in the liver and affects liver functions. This ...

作者： Qian Wang;Yu-Long Bie;Dou Wang;Wen-Tao Fan （Shanxi University of Chinese Medicine, Xianyang 712046, China. Shanxi University of Chinese Medicine, Xianyang 712046, China. Shanxi University of Chinese Medicine, Xianyang 712046, China.）

出处： Chinese journal of applied physiology 2017

关键词： IL-6/STAT3 signaling pathway;dandelion polysaccharide;inflammatory bowel disease;rat model;regulation

摘要： OBJECTIVE: To investigate the effects of dandelion polysaccharide on IL-6/STAT3 signaling pathway in rats with ulcerative colitis. METHODS: Forty SD r ...

作者： Tang, Li¹;Luo, Jie-ran¹;Li, Yun-lan¹;Ge, Rui¹;Li, Qing-shan^1,2 （1 School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, PR China 2 Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, PR China）

出处： Environmental Toxicology & Pharmacology 2017

关键词： Di- n -butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT);Hepatotoxicity;Mechanism

摘要： Di- n -butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) is an anti-tumour organotin(IV) compound with hepatotoxicity. To investigate the hepatotoxic ...

作者： Huo, Junfeng^1,2;Dong, Aiguo²;Wang, Yonghui²;Lee, Shaochin¹;Ma, Cungen^2,3;Wang, Lan¹ （1 School of Life Science, Shanxi University, Taiyuan, Shanxi Province, China 2 2011 Collaborative Innovation Center/Research Center of Neurobiology, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi Province, China 3 Institute of Brain Science, Shanxi Datong University, Datong, Shanxi Province, China）

出处： Chemosphere 2017

关键词： Cadmium;Freshwater turtle;Liver;Structural changes

摘要： The study investigated the histopathological and ultrastructural lesions of liver of freshwater turtle Chinemys reevesii exposed to Cadmium (Cd). The ...

作者： Chen J.;Liu J.;Cui D.;Yan C.;Meng L.;Sun L.;Ban S.;Ge R.;Liang T.;Li Q. （1 Laboratory of Medicinal Chemistry, School of Pharmaceutical Science, Shanxi Medical University, 2 College of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, People’s Republic of China *These authors contributed equally to this work）

出处： Drug Design, Development and Therapy 2017

关键词： 4-methoxy-substituted and 5-methyl-substituted (3'S,4'S)-(-)-cis-khellactones;synthesis;cytotoxic activity;apoptosis

摘要： This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3'S,4'S)-(-)-cis-khellactones. The ...