作者： Shaozhen Guo  ¹, Yuting Gao  ¹, Yuwei Zhao  ¹ （Affiliation ¹ College of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030619, P. R. China.）

出处： ACS chemical neuroscience 2023

关键词： EGR1;PTEN;Parkinson’s disease;dopaminergic neuron;microRNA-381;oxidative stress injury;p53.

摘要： As a common and disabling disease of the elderly, the standard therapies of Parkinson's disease (PD) fail to curb the ongoing neurodegeneration, thus ...

作者： Gaihui Li  ¹, Hongyu Zhang  ¹, Guoshun Zhang  ¹, Bei Wei  ¹, Bin Liu  ¹, Heng Song  ^{1   2}, Qingshan Li  ^{1   3}, Shurong Ban  ¹ （Affiliations ¹ School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi 030001, China. ² College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. ³ Shanxi Key laboratory of Chronic Inflammatory Targeted Drugs, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi 030619, China.）

出处： The Journal of organic chemistry 2023

关键词： ENANTIOSELECTIVE SYNTHESIS;1,3-DIPOLAR CYCLOADDITION;UNSATURATED PYRAZOLONES;CASCADE;CONSTRUCTION;DERIVATIVES;SCAFFOLDS;INHIBITORS;OXINDOLES;THIOLS

摘要： An enantioselective synthesis of spiropyrazolone-fused dihydrofuran-naphthoquinones is first demonstrated via a Michael addition/Chlorination/Nucleoph ...

作者： Xiaokang Li  ¹, Bei Wei  ¹, Yanlong Gong  ¹, Chengyi Li  ¹, Xiaoting Liu  ¹, Bin Liu  ¹, Qingshan Li  ^{1   2}, Shurong Ban  ¹ （Affiliations ¹ School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi 030001, China. ² Shanxi Key Laboratory of Chronic Inflammatory Targeted Drugs, Shanxi University of Traditional Chinese Medicine, Jin-zhong, Shanxi 030619, China.）

出处： The Journal of organic chemistry 2023

摘要： The decarboxylative coupling using carboxylic acid and potassium metabisulfite, promoted by a palladium catalyst, is reported for the generation of su ...

作者： Shuyun Wang  ¹, Xuyan Wang  ², Xiaohong Liu  ³, Chenxing Zhao  ⁴, Jinju Duan  ¹ （Affiliations ¹ Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. ² School of Traditional Chinese Medicine and Food Engineering, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, China. ³ Department of Pharmacy, Yangquan First People's Hospital, Yangquan, Shanxi, China. ⁴ Department of Pharmacy, Linfen People's Hospital, Linfen, Shanxi, China.）

出处： Frontiers in psychiatry 2023

关键词： cancer pain;humanistic care;pain intensity;psychological factors;psychological functions.

摘要： Objective: The objective of this study is to explore whether humanistic care practiced by clinical pharmacists and socioeconomic status moderate the a ...

作者： Tao Tong^1,2,3;Yiping Chen^1,2,3;Chonyao Hao^1,3;Junliang Shen²;Wenjie Chen²;Wenjing Cheng⁴;Simin Yan²;Jianguo Li¹;Yuhan Li⁵;Tuergong Gulizhaerkezi²;Xianjun Meng²CA1 （¹Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, P. R. China;²Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, P. R. China;³These authors have contributed equally to this work and share first authorship;⁴Department of Rehabilitation Medicine, Ezhou Central Hospital, Ezhou, Hubei, P. R. China;⁵The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, P. R. China）

出处： Behavioural Brain Research 2023

关键词： Acupuncture;BDNF/TrkB/CREB signaling;Chronic unpredictable mild stress;Depression;Synaptic Plasticity.

摘要： Depression is a major mental disease worldwide, causing dysfunction of Lateral Habenular (LHb). As a non-invasive alternative, acupuncture (AP) has be ...

作者： Huiying Bai  ¹, Zhen Cao  ¹, Sha Meng  ¹, Rui Ge  ¹, Shurong Ban  ¹, Yuanlin Zhang  ², Li Tang  ³, Qingshan Li  ¹ （Affiliations ¹ Shanxi Medical University, Pharmaceutical Science, 56 Xinjian South Road, taiyuan, CHINA. ² SUTCM: Shanxi University of Traditional Chinese Medicine, Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, 121 University Street, University Parks in Shanxi Province, jinzhong, CHINA. ³ Shanxi Medical University, Pharmaceutical science, 56 Xinjian Road South, 030001, taiyuan, CHINA.）

出处： Chemistry & biodiversity 2023

关键词： anti-inflammatory;benzoxazole derivatives;IL-6;myeloid differentiation protein 2;synthesis.

摘要： Myeloid differentiation protein 2 (MD2), a key TLR4 adaptor protein for sensing LPS, plays an important role in inflammatory process and has been iden ...

作者： Nan Nan ^1,2,3;Qi Wang ^1,2;Mei-Jing Li ^1,2;Yong-Song Xu ^4,5;Xiao-Meng Guo ^1,2;Rui Xu ^1,2;Zhe Ma ^1,2;Si-Hui Wang ^1,2;Jing Li ^1,2;Hui Zhao ^1,2 and Mu-Xin Gong ^1,2 （^1, School of Traditional Chinese Medicine , Capital Medical University , Beijing 100069 ;^2, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research , Beijing 100069 ;^3, Shanxi University of Traditional Chinese Medicine , Shanxi 030619 ;^4, Center for Endocrine Metabolism and Immune Diseases , Beijing Luhe Hospital , Capital Medical University , Beijing 101149 ;^5, Beijing Key Laboratory of Diabetes Research and Care , Beijing 101149）

出处： Oxidative Medicine and Cellular Longevity 2023

关键词： Medicamentos de Ervas Chinesas;Microbiota;Transtornos de Enxaqueca;Animais;Ratos;Ansiedade/tratamento farmacológico;Depressão/tratamento farmacológico;Transtornos de Enxaqueca/tratamento farmacológico;Serotonina;Medicamentos de Ervas Chinesas/farmacologia

摘要： We previously found that Wuzhuyu Decoction (WZYD) could affect central and peripheral 5-HT to relieve hyperalgesia in chronic migraine (CM) model rats ...

作者： Dekang Yan¹;Xiuwu Qu²;Muhan Chen¹;Jiahua Wang¹;Xiuying Li²;Zixu Zhang¹;Yang Liu¹;Liang Kong¹;Yang Yu¹;Ruijun Ju³CA1;Xuetao Li¹CA2 （¹School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China;²Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China;³Beijing Key Laboratory of Enze Biomass Fine Chemicals, Beijing Institute of Petrochemical Technology, Qingyuan North Road 19, 102617, Beijing, China）

出处： Journal of Drug Delivery Science and Technology 2023

摘要： The brain is a crucial organ in the body, shielded from external substances by the blood-brain barrier (BBB). However, this barrier also impedes the t ...

作者： Caixia Zhang;Weiyan Wang;Chenhui Du;Huifang Li;Kun Zhou;Zhihua Luan;Yinxia Chang;Shan Liu;Yanming Wei （College of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China, Shanxi Institute of Energy, Taiyuan, Shanxi 030600, P.R. China, Experimental Management Center, Shanxi University of Chinese Medicine, Jinzhong, Shanxi 030619, P.R. China）

出处： Experimental and Therapeutic Medicine 2023

关键词： anti-atherosclerosis;anti-inflammatory;anti-macular degeneration;anti-pulmonary fibrosis;anti-tumor;autophagy;celastrol;immunomodulatory;neuroprotective.

摘要： Celastrol, a natural compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii Hook F, possesses broad‑spectrum pharmacolo ...

作者： Xiao-Ying Li  ¹, Dong-Xia Sun  ¹, Ya-Ni Xu  ², Xiao-Han Gao  ¹, Kai-Fang Fan  ³ （Affiliations ¹ Shanxi University of Chinese Medicine Jinzhong 030619, China. ² Zhejiang Chinese Medical University Hangzhou 310000, China. ³ Shanxi University of Chinese Medicine Jinzhong 030619, China Affiliated Hospital of Shanxi University of Chinese Medicine Taiyuan 030024, China.）

出处： Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2023

关键词： GRADE;Guanxinning Tablets;Meta-analysis;angina pectoris;coronary heart disease;effectiveness.

摘要： This study aims to evaluate the efficacy and safety of Guanxinning Tablets+conventional western medicine in the treatment of angina pectoris of corona ...