作者: Zhao Zhang;Yun Zhang;Zheng Mou;Shifeng Chu;Xiaoyu Chen;Wenbin He;Xiaofeng Guo;Yuhe Yuan;Masami Takahashi ;Naihong Chen (State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China, Basic Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China ; Basic Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China ; Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan ; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China)
出处: PLOS ONE 2014 Vol.9 No.4 Pe94574
摘要: Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship ...
作者: Guo, AL;Zhang, SR;Liu, XF;Jiao, JH (aDepartment of Traditional Chinese Pharmacology, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, People's Republic of China)
出处: Acta crystallographica. Section E: Structure reports online 2011 Vol.67 PO285-U2086
摘要: The title compound, C(19)H(17)NO(2), represents a trans isomer with respect to the C=N bond. The dihedral angle between the planes of the naphthyl rin ...
作者: 杨丽霞,黄海华,郭维婷,韩思思,刘慧敏,薛舒 (山西中医药大学中药与食品工程学院)
出处: 包装与食品机械 2024
关键词: 辣椒红色素;色价;正交试验;响应面试验
摘要: 为优化超声辅助热浸提辣椒红色素的工艺,选用“北京红”辣椒为原料,通过正交试验和响应曲面法分析超声时间、超声温度、料液比、热浸温度、热浸时间和提取次数对产品色价的影响,确定最佳提取工艺。采用皂化去酯法对所得辣椒红色素进一步纯化。试验结果表明,超声时间、超声温度、热浸提时间对辣椒红色素色价有显著影响,以 ...
作者: 戴铭成,秦楠 (晋中信息学院食品与环境学院;山西中医药大学中药与食品工程学院)
出处: 中国调味品 2024
关键词: 山楂;发酵;微生物;风味物质
摘要: 自然环境条件下发酵的果醋风味优于单一菌株发酵的果醋,然而,自然发酵的山楂果醋发酵周期长且品质不稳定。通过人工接种的方式可以缩短山楂果醋的发酵时间,稳定山楂果醋的品质,但单一菌株又会导致山楂果醋口感单一,缺乏市场竞争力。为了探究单一菌株和混合菌株醋酸发酵对山楂果醋品质的影响,该研究通过GC-MS技术对 ...
作者: 张春青,唐坤鹏,闫丽萍,文坛,王海军 (山西中医药大学)
出处: 海南医学院学报 2024
关键词: 电针;不同腧穴;急性结肠炎;炎症因子;JAK2/STAT3/SOCS1信号通路
摘要: 目的:探讨JAK2/STAT3/SOCS1信号通路在电针不同腧穴对大鼠急性结肠炎的作用机制。方法:将36只SPF级SD大鼠随机分为6组,每组6只。除正常组外,其余各组用冰乙酸溶液灌肠制备急性结肠炎大鼠模型,在造模结束后给予各腧穴组电针治疗,疏密波,频率2~50 Hz,强度2 mA,以肌肉震颤为度,2 ...
作者: 谭丹丹1,冯振宇2,孟霜2,王旭艳1,王鑫鑫2,赵杰1,2,赵建平2 (1山西中医药大学;2山西省中西医结合医院)
出处: 海南医学院学报 2024
关键词: 扶阳解表颗粒;网络药理学;药效学;病毒性肺炎;分子对接;经方扶阳
摘要: 目的:本研究旨在探究扶阳解表颗粒(FYJBKL)对病毒性感染肺炎的治疗作用机制。方法:利用网络药理学所建立的网络模式,研究FYJBKL病毒性肺炎的目标表达点,从而确定治疗病毒性肺炎的主要靶点和重要的信号传递途径。其次,将药品中的主要组成部分和主要靶点进行对接;然后,建立发热、发汗和炎症大鼠模型以探索 ...
作者: 孙启蒙,李晓丽,刘丽坤 (山西中医药大学;山西省中医院)
出处: 湖南中医药大学学报 2024
关键词: 周围神经病变;紫杉醇;伏毒;络病;通调营卫;化瘀解毒;扶阳托毒;刘丽坤
摘要: 周围神经病变是紫杉醇药用后常见的不良反应,其症状缠绵难愈且容易复发。结合其临床表现,刘丽坤教授从中医学的“伏毒-络病”角度进行论治,认为药毒损络致络脉失和是核心病机,毒、瘀、虚是其发生、发展的内在病理因素。治疗上根据络病传变规律和不同阶段的伏毒病机特点分期辨治:急性发作期通达气络,调和营卫;慢性难愈 ...
作者: 唐坤鹏,吕嘉琪,文坛,张春青,马梦娜,高婷,闫丽萍 (山西中医药大学)
出处: 现代中西医结合杂志 2024
关键词: 慢性结肠炎;电针;腧穴特异性;肿瘤坏死因子-α;白细胞介素-10;基质金属蛋白酶-1;基质金属蛋白酶-2
摘要: 目的 探讨电针慢性结肠炎大鼠天枢、大肠俞、足三里、上巨虚对结肠炎症的效应差异及机制。方法 60只SD大鼠饲养1周后,随机分为正常组、模型组和天枢组、大肠俞组、足三里组、上巨虚组各10只。除正常组外,其余组大鼠采用免疫复合致敏法建立慢性结肠炎模型,各腧穴组于造模结束后行相应穴位电针干预,参数为2 Hz ...
作者: 霍凯,李廷荃,张晓园,王晓梅,王振雄 (山西中医药大学研究生学院;山西中医药大学附属医院国医堂;山西省中医院)
出处: 现代中西医结合杂志 2024
关键词: 反流性食管炎;“致中和”思想;顺胃降逆方;中医治疗;临床经验
摘要: 反流性食管炎是一种消化系统多发性疾患,其致病因素多样,以反流、烧心为其主要临床表现。近些年来,中医以辨证论治、审证求因等为诊治原则,在反流性食管炎的治疗上取得了良好的临床疗效。李廷荃教授根据“致中和”理论提出,本病主因肝、脾、胃不和,寒、湿、热兼杂而发作,治疗时选用半夏泻心汤为基础方,自拟顺胃降逆方 ...
作者: 黄益清,温煜杰,郑璐璐,张俐敏 (山西中医药大学基础医学院)
出处: 中国现代中药 2024
关键词: 经典名方;驻景丸;《太平圣惠方》;历史沿革;方证信息;文献考证
摘要: 驻景丸是2023 年《古代经典名方目录(第二批)》汉族医药的第40 首,出自北宋《太平圣惠方》,由菟丝子、车前子、熟地黄3 味药组成,功用补益肝肾、清热明目,主治肝肾亏虚之眼病,为中医眼科临床常用名方。采用文献统计学方法,搜集分析驻景丸的古今文献,共筛选有效古籍数据63 条,涉及47 部中医古籍。从 ...
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