作者： Liu, Chun-yun¹;Guo, Shang-de¹;Yu, Jie-zhong¹;Li, Yan-hua¹;Zhang, Hui¹;Wang, Qing²;Chai, Zhi²;Feng, Ling¹;Huang, Jian-jun³;Feng, Qian-jin²;Xiao, Bao-guo⁴;Ma, Cun-gen¹ （a Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong, Chinab “2011” Collaborative Innovation Center/Department of Encephalopathy and National Major Clinical Department of Ministry of Health, Shanxi University of Traditional Chinese Medicine, Taiyuan, Chinac Department of Neurosurgery, First Hospital, Datong Coalmine Group, Datong, Chinad Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China）

出处： Journal of Neuroimmunology 2014 Vol.275 No.1-2 P223

摘要： Background: To study the roles of Fasudil on macrophages, T cells and TLR-4/NF-kappaB signaling pathway for the mechanisms underlying the amelioration ...

作者： Chun-Yun Liu^a;Shang-De Guo^a;Jie-Zhong Yu^a;Yan-Hua Li^a;Hui Zhang^a;Zhi Chai^b;Qing Wang^b;Ling Feng^a;Jian-Jun Huang^c;Qian-Jin Feng^b;Bao-Guo Xiao^d,⁎;Cun-Gen Ma^{a, b,⁎} （a Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong, Chinab “2012” collaborative Innovation Center, Shanxi University of Traditional Chinese Medicine, Taiyuan, Chinac Department of Neurosurgery, First Hospital, Datong Coalmine Group, Datong, Chinad Institute of Neurology, Huashan Hospital, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China）

出处： Journal of Neuroimmunology 2014 Vol.275 No.1-2 P142-143

摘要： Background: To study the roles of Fasudil on macrophages, T cells and TLR-4/NF-kappaB signaling pathway for the mechanisms underlying the amelioration ...

作者： Yan-Hua Li¹;Jie-Zhong Yu¹;Chun-Yun Liu¹;Hui Zhang¹;Hai-Fei Zhang¹;Wan-Fang Yang²;Jun-Lian Li²;Qian-Jin Feng²;Ling Feng¹;Guang-Xian Zhang³;Bao-Guo Xiao⁴;Cun-Gen Ma^1,2 （1Department of Neurology Institute of Brain Science Medical School, Shanxi Datong University, Datong, China2Department of Encephalopathy and National Major Clinical Department of the Ministry of Health Third Hospital, Shanxi University of Traditional Chinese Medicine, Taiyuan, China3Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA4Institute of Neurology Huashan Hospital Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China）

出处： Immunology 2014 Vol.143 No.2 P219-229

关键词： Anti-inflammatory;Experimental autoimmune encephalomyelitis;FSD-C10-Fasudil derivative;Intranasal route;Neuroprotection

摘要： Viewing multiple sclerosis (MS) as both neuroinflammation and neurodegeneration has major implications for therapy, with neuroprotection and neurorepa ...

作者： Min-Fang Guo^a;Jian Meng^a;Yan-Hua Li^a;Jie-Zhong Yu^a;Chun-Yun Liu^a;Ling Feng^a;Wan-Fang Yang^c;Jun-Lian Li^c;Qian-Jin Feng^c;Bao-Guo Xiao^{b, ,} ;Cun-Gen Ma^{a, c, ,} （a Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong, Chinab Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, Chinac Department of Encephalopathy and National Major Clinical Department of Ministry of Health, Third Hospital, Department of Neurology, Shanxi University of Traditional Chinese Medicine, Taiyuan, China）

出处： Journal of the Neurological Sciences 2014 Vol.343 No.1-2 P69-75

关键词： Astrocytes;Chemokines;Cytokines;Experimental autoimmune encephalomyelitis;Fasudil;Rho kinase inhibitor

摘要： Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune diseases characterized by the immune-med ...

作者： Jia-Qing Yan ;Yu-He Yuan ;Yan-Na Gao ;Ju-Yang Huang ;Kai-Li Ma ;Yan Gao ;Wan-Qing Zhang ;Xiao-Feng Guo ;Nai-Hong Chen （1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, I Xiannongtan Street, Xicheng District, 100050, Beijing, People’s Republic of China2. Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China3. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Beijing, People’s Republic of China4. Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China）

出处： Molecular Neurobiology 2014 Vol.50 No.2 P685-701

关键词： Parkinson’s disease;E46K mutant α-synuclein;Autophagy;JNK1;Bcl-2

摘要： Parkinson’s disease (PD) is pathologically characterized by selective loss of dopaminergic neurons in the midbrain and the existence of intracellular ...

作者： （1Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200040, China.2Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China.31] Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong 037009, China [2] Department of Encephalopathy and National Major Clinical Department of Ministry of Health, Third Hospital, Shanxi University of Traditional Chinese Medicine, Taiyuan 030006, China.）

出处： Acta Pharmacologica Sinica 2014 Vol.35 No.11 P1428-1438

摘要： AIM: Fasudil, a selective Rho kinase (ROCK) inhibitor, has been shown to alleviate the severity of experimental autoimmune encephalomyelitis (EAE) via ...

作者： Jia-Qing Yan ;Yu-He Yuan ;Yan-Na Gao ;Ju-Yang Huang ;Kai-Li Ma ;Yan Gao ;Wan-Qing Zhang ;Xiao-Feng Guo ;Nai-Hong Chen （1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, I Xiannongtan Street, Xicheng District, 100050, Beijing, People’s Republic of China2. Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China3. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Beijing, People’s Republic of China4. Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China）

出处： Molecular Neurobiology 2014 Vol.50

摘要： Erratum to: Mol Neurobiol DOI 10.1007/s12035-014-8738-1 The original version of the article unfortunately contains mistake on Fig. 2a as the upper ima ...

作者： Zhang, Zhao¹;Zhang, Yun¹;Mou, Zheng¹;Chu, Shifeng¹;Chen, Xiaoyu¹;He, Wenbin^1,2;Guo, Xiaofeng²;Yuan, Yuhe¹;Takahashi, Masami³ masami@med.kitasato-u.ac.jp;Chen, Naihong¹ chennh@imm.ac.cn （11 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Department of Pharmacology, Institute of Materia Medica, and neuroscience center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China22 Basic Medical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, People’s Republic of China33 Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan）

出处： PLoS ONE 2014 Vol.9 No.4 P1-12

关键词： Biochemistry;Biology and life sciences;Cell biology;Cell signaling;Medicine and health sciences;Molecular cell biology;Molecular neuroscience;Neurobiology of disease and regeneration;Neurochemistry;Neurological signaling;Neurology;Neuroscience;Neurotransmitters;Research Article;Signal transduction;Tyrosine kinase signaling cascade

摘要： Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship ...

作者： Ying-li Wang ^, ;Yan Wang （Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, China）

出处： Chinese Herbal Medicines 2014 Vol.6 No.2 P120-124

关键词： amount of gastric emptying;gastrointestinal motility;serum motilin;Sijunzi Dripping Pill

摘要： Objective To study the effects of Sijunzi Dripping Pill (SDP) on gastrointestinal motility of mice. Methods The diarrhea and swimming model of mice wa ...

作者： Yu-Min Zhang;Jian-Ru Wang;Nai-Li Zhang;Xiao-Ming Liu;Mo Zhou;Shao-Ying Ma;Ting Yang;Bao-Xing Li （1. Shanxi University of Traditional Chinese Medicine, Taiyuan, China2. Shanxi Medical University, Taiyuan, China3. Shanxi University, Taiyuan, China4. China Institute for Radiation Protection, Taiyuan, China）

出处： Cell and Tissue Banking 2014 Vol.15 No.3 P291-296

摘要： Before 1986, the development of tissue banking in China has been slow and relatively uncoordinated. Under the support of International Atomic Energy A ...