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李俊莲

基础医学院

职称：教授

李俊莲所有成果
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[外文期刊] Intranasal delivery of FSD-C10, a novel Rho kinase inhibitor, exhibits therapeutic potential in experimental autoimmune encephalomyelitis.

作者：Yan-Hua Li1;Jie-Zhong Yu1;Chun-Yun Liu1;Hui Zhang1;Hai-Fei Zhang1;Wan-Fang Yang2;Jun-Lian Li2;Qian-Jin Feng2;Ling Feng1;Guang-Xian Zhang3;Bao-Guo Xiao4;Cun-Gen Ma1,2 （1Department of Neurology Institute of Brain Science Medical School, Shanxi Datong University, Datong, China2Department of Encephalopathy and National Major Clinical Department of the Ministry of Health Third Hospital, Shanxi University of Traditional Chinese Medicine, Taiyuan, China3Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA4Institute of Neurology Huashan Hospital Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China）

出处：Immunology 2014

关键词：Anti-inflammatory;Experimental autoimmune encephalomyelitis;FSD-C10-Fasudil derivative;Intranasal route;Neuroprotection

摘要：Viewing multiple sclerosis (MS) as both neuroinflammation and neurodegeneration has major implications for therapy, with neuroprotection and neurorepa ...

[外文期刊] The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes.

作者：Min-Fang Guoa;Jian Menga;Yan-Hua Lia;Jie-Zhong Yua;Chun-Yun Liua;Ling Fenga;Wan-Fang Yangc;Jun-Lian Lic;Qian-Jin Fengc;Bao-Guo Xiaob, Corresponding author contact information Corresponding author contact information , E-mail the corresponding author E-mail the corresponding author;Cun-Gen Maa, c, Corresponding author contact information Corresponding author contact information , E-mail the corresponding author E-mail the corresponding author （a Institute of Brain Science, Department of Neurology, Medical School, Shanxi Datong University, Datong, Chinab Institute of Neurology, Huashan Hospital, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, Chinac Department of Encephalopathy and National Major Clinical Department of Ministry of Health, Third Hospital, Department of Neurology, Shanxi University of Traditional Chinese Medicine, Taiyuan, China）

出处：Journal of the Neurological Sciences 2014

关键词：Astrocytes;Chemokines;Cytokines;Experimental autoimmune encephalomyelitis;Fasudil;Rho kinase inhibitor

摘要：Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune diseases characterized by the immune-med ...

[中文期刊] 潮湿环境下大鼠脾组织差异蛋白组学研究 CA 剑桥 CSCD

作者：刘芳芳，王平，李俊莲，邱继云，陶功定 （山西中医学院；太原市中心医院北院）

出处：中华中医药杂志 2017

关键词：湿邪  脾组织  差异蛋白组学  潮湿环境  载脂蛋白A-I  肌动蛋白相关蛋白2/3复合物亚基5  结合珠蛋白

摘要：目的:通过比较正常及潮湿环境下大鼠脾组织蛋白质谱,筛选和鉴定与湿邪有关的疾病特异性蛋白,探寻湿邪致病的生物标志物。方法:选取SD大鼠20只随机分为对照组、外湿组,每组10只。造模成功后无菌摘除脾脏,取出脾组织10mg/只,进行双向电泳实验、双向凝胶电泳图象分析,肽质量指纹图谱与电喷雾串联质谱鉴定蛋白 ...

[中文期刊] 正常及脾阳虚大鼠脾组织蛋白组学差异分析 核 CA 剑桥 CSCD

作者：刘芳芳，王平，陶功定，李俊莲，邱继云 （山西中医学院；太原市中心医院北院）

出处：中华中医药杂志 2016

关键词：脾阳虚  脾组织  差异蛋白质  蛋白组学

摘要：目的:通过比较正常及脾阳虚大鼠脾组织蛋白质谱,筛选和鉴定与脾阳虚证有关的疾病特异性蛋白,探寻脾阳虚证生物标志物。方法:选取SD大鼠20只随机分为对照组、脾阳虚组,每组10只。造模成功后无菌摘除脾脏,取出脾组织10mg/只,进行双向电泳实验、双向凝胶电泳图象分析,肽质量指纹图谱与电喷雾串联质谱鉴定蛋白 ...